公开(公告)号：US20170360884A1

公开(公告)日：2017-12-21

申请号：US15537051

申请日：2015-12-29

Applicant: ACADEMIA SINICA

Inventor： Shie-Liang HSIEH ,  Yung-Chi CHANG ,  Ming-Ting HUANG

IPC: A61K38/17 ,  C07K14/705

CPC classification number: A61K38/177 ,  C07K14/70578 ,  C07K2319/30

Abstract: Disclosed herein is a method of treating influenza A virus (IAV) infection by a fusion protein. According to some embodiments of the present disclosure, the fusion protein comprises a HBD peptide and a IgG1 Fc region. According to other embodiments of the present disclosure, the fusion protein comprises a DcR3 protein and a IgG1 Fc region. The present fusion protein is found to possess inhibitory effects on IAV-induced secretion of the inflammatory cytokine, and IAV-induced infiltration of inflammatory cell into the lung tissue. Accordingly, the fusion protein is useful for developing a medicament for the treatment or prophylaxis of IAV infection and/or ameliorating pulmonary injury caused by excessive inflammation associated with IAV infection in a subject.