公开(公告)号：US11376325B2

公开(公告)日：2022-07-05

申请号：US16899729

申请日：2020-06-12

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Steven G. Reed ,  Darrick Carter

IPC: A61K39/395 ,  A61K39/39 ,  A61K39/008 ,  A61K45/06 ,  A61K39/04 ,  A61K39/145 ,  A61K39/00 ,  C12N7/00

Abstract: Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.