公开(公告)号：US11369672B2

公开(公告)日：2022-06-28

申请号：US16126285

申请日：2018-09-10

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Steven G. Reed ,  Rhea N. Coler

IPC: A61K39/04 ,  A61K31/4409 ,  A61K31/496 ,  A61K39/39 ,  A61K45/06 ,  A61K39/00

Abstract: The present disclosure relates to methods and compositions for treating a active tuberculosis infection and methods and compositions for improving the efficacy of chemotherapy regimens against active tuberculosis infection. The present disclosure relates to methods of treating an active M. tuberculosis infection or an active infection resulting from reactivation of a latent infection in a mammal and to methods of improving the efficacy of chemotherapy regimens against active M. tuberculosis infection.

公开(公告)号：US11897922B2

公开(公告)日：2024-02-13

申请号：US17367812

申请日：2021-07-06

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Steven G. Reed ,  Rhea N. Coler ,  Gregory C. Ireton ,  Sylvie Bertholet

IPC: C07K14/35 ,  A61K39/04 ,  C07K14/285 ,  G01N33/569 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K14/35 ,  A61K39/04 ,  C07K14/285 ,  G01N33/5695 ,  G01N33/68 ,  A61K2039/55561 ,  C07K2319/00 ,  G01N2469/20 ,  Y02A50/30

Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp.) antigens, and polynucleotides encoding such compositions and fusion proteins. The invention also relates to methods for their use in the treatment, prevention and/or diagnosis of tuberculosis infections.