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公开(公告)号：US11532381B2
公开(公告)日：2022-12-20
申请号：US16070117
申请日：2017-01-12
申请人： ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. , THE ADMINISTRATORS OF THE TULANE EDUCATION FUND
摘要： Method, device, and system for identifying a model-based time dependent light scattering signature that includes receiving an experimental time dependent light scattering signature comprising experimental data descriptive of an average molecular weight of protein components in a solution over time. The method further includes identifying an Ansatz for evaluating the experimental time dependent light scattering signature, the Ansatz being an initial model-based time dependent light scattering signature, the initial model-based time dependent light scattering signature identifying at least one key variable. The method also includes adjusting the at least one key variable in the initial model-based time dependent light scattering signature until a final model-based time dependent light scattering signature is identified. In some instances, the final model-based time dependent light scattering signature identifies at least one protein aggregation mechanism.
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公开(公告)号：US20190025178A1
公开(公告)日：2019-01-24
申请号：US16070117
申请日：2017-01-12
申请人： ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. , THE ADMINISTRATORS OF THE TULANE EDUCATION FUND
摘要： Method, device, and system for identifying a model-based time dependent light scattering signature that includes receiving an experimental time dependent light scattering signature comprising experimental data descriptive of an average molecular weight of protein components in a solution over time. The method further includes identifying an Ansatz for evaluating the experimental time dependent light scattering signature, the Ansatz being an initial model-based time dependent light scattering signature, the initial model-based time dependent light scattering signature identifying at least one key variable. The method also includes adjusting the at least one key variable in the initial model-based time dependent light scattering signature until a final model-based time dependent light scattering signature is identified. In some instances, the final model-based time dependent light scattering signature identifies at least one protein aggregation mechanism.
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