公开(公告)号：US20200061167A1

公开(公告)日：2020-02-27

申请号：US16346855

申请日：2017-11-07

申请人： ADVAXIS, INC.

发明人： Sandra M. HAYES ,  Rachelle KOSOFF ,  Jun ZOU

IPC分类号： A61K39/00 ,  C07K16/28 ,  A61K39/395 ,  A61K39/12 ,  A61P35/00

摘要： The subject matter described herein is directed to methods of treating, protecting against, and inducing an immune response against a human papillomavirus-associated tumor or cancer, comprising the step of administering to a subject a recombinant Listeria strain expressing a construct comprising at least one human papillomavirus antigen in combination with one or more other therapeutic agents to treat a tumor or metastatic cancer.