公开(公告)号：US10729752B2

公开(公告)日：2020-08-04

申请号：US15699951

申请日：2017-09-08

申请人： AERASE, INC.

发明人： David Lowe ,  Scott W. Rowlinson ,  Susan Alters ,  Giulia Agnello

IPC分类号： A61K38/50 ,  A61K39/395 ,  C07K16/28 ,  A61P35/00 ,  C07K19/00 ,  C12N9/78 ,  A61K9/00 ,  A61K39/00

摘要： Methods of treating tumors or cancer include administration of an arginine depleting enzyme and an immune-oncology agent.

公开(公告)号：US11717562B2

公开(公告)日：2023-08-08

申请号：US16210248

申请日：2018-12-05

申请人： AERase, Inc.

发明人： Scott W. Rowlinson ,  Anthony G. Quinn ,  Ann Lowe ,  David Lowe

IPC分类号： A61K38/00 ,  A61K47/00 ,  A61K38/50 ,  A61K9/00 ,  A61K48/00 ,  A61K45/06 ,  A61P3/00 ,  A61K47/60 ,  A61K38/51

CPC分类号： A61K38/50 ,  A61K9/0019 ,  A61K38/51 ,  A61K45/06 ,  A61K47/60 ,  A61K48/005 ,  A61P3/00 ,  C12Y305/03001

摘要： A method and composition to treat a subject with arginase 1 (ARG1) deficiency (ARG1-D) and to rapidly reduce the levels of at least one of arginine and/or a guanidino compound in the subject.

公开(公告)号：US20210379167A1

公开(公告)日：2021-12-09

申请号：US17286041

申请日：2019-10-18

申请人： Aerase, Inc.

发明人： Anthony G. Quinn ,  Andreas Schulze ,  Scott W. Rowlinson

IPC分类号： A61K38/50

摘要： Methods and compositions therefor of treating GAMT deficiency or guanidino acetate (GAA) toxicity in a subject comprising administration of an arginine depleting enzyme. An therapeutic formulation can include an arginase, an arginine deiminase or a combination thereof and optionally other compounds, and can be adapted for intravenous or subcutaneous administration to a subject.