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    Polypeptides having affinity for HER2
    1.
    发明授权
    Polypeptides having affinity for HER2 有权
    对HER2具有亲和力的多肽

    公开(公告)号：US08883120B2

    公开(公告)日：2014-11-11

    申请号：US13928522

    申请日：2013-06-27

    Applicant: Affibody AB

    Inventor： Lars Abrahmsén ,  Nina Herne ,  Joachim Feldwisch ,  Christofer Lendel ,  Vladimir Tolmachev

    IPC: A61K51/08 ,  A61K38/00

    CPC classification number: A61K51/08 ,  A61K38/00 ,  A61K51/088 ,  C07K16/32

    Abstract: HER2 binding polypeptides comprising the amino acid sequence EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ wherein X1 in position 2 is M, I or L, and X2 in position 39 is S or C (SEQ ID NO:1) are disclosed. Moreover, such peptides comprising a chelating environment are disclosed. Also radiolabeled polypeptides formed by the peptides comprising a chelating environment and radionuclides are disclosed. Furthermore, methods of in vivo imaging of the body of a mammalian subject having or suspected of having a cancer characterized by overexpression of HER2 comprising administration of such a radiolabeled polypeptide followed by obtainment of an image of the body using a medical imaging instrument and also methods of treating such cancer are disclosed. Furthermore, the use of such a radiolabeled polypeptide in diagnosis and treatment of cancer characterized by overexpression of HER2. Nucleic acids encoding the polypeptides, expression vectors comprising the nucleic acids and host cells comprising the expression vectors are also disclosed.

    Abstract translation: HER2结合多肽包含氨基酸序列EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ，其中位置2中的X1是M，I或L，而位置39的X2是S或C（SEQ ID NO：1）。 此外，公开了包含螯合环境的这些肽。 还公开了由包含螯合环境和放射性核素的肽形成的放射性标记的多肽。 此外，具有或怀疑具有HER2过表达的哺乳动物受试者的身体的体内成像方法包括施用这种放射性标记的多肽，然后使用医学成像仪获得身体的图像，以及方法 公开了治疗这种癌症的方法。 此外，这种放射性标记的多肽在诊断和治疗HER2过表达的癌症中的应用。 还公开了编码多肽的核酸，包含核酸的表达载体和包含表达载体的宿主细胞。

    Polypeptide libraries with a predetermined scaffold
    3.
    发明授权
    Polypeptide libraries with a predetermined scaffold 有权

    公开(公告)号：US10556933B2

    公开(公告)日：2020-02-11

    申请号：US15238184

    申请日：2016-08-16

    Applicant: Affibody AB

    Inventor： Lars Abrahmsén ,  Nina Herne ,  Christofer Lendel ,  Joachim Feldwisch

    IPC: C40B40/10 ,  C07K14/31 ,  C12N15/10 ,  C07K1/04 ,  G01N33/68

    Abstract: Populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ (SEQ ID NO: 1) or AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q (SEQ ID NO: 2), wherein each X individually corresponds to an amino acid residue which is varied in the population are disclosed. Also populations of polynucleotides, wherein each member encodes a member of a polypeptide population are disclosed. Furthermore, combinations of such polypeptide populations and such polynucleotide populations are disclosed, wherein each member of polypeptide population is physically or spatially associated with the polynucleotide encoding that member via means for genotype-phenotype coupling.

    POLYPEPTIDES HAVING AFFINITY FOR HER2
    7.
    发明申请
    POLYPEPTIDES HAVING AFFINITY FOR HER2 有权
    具有HER2的亲和力的多肽

    公开(公告)号：US20130280164A1

    公开(公告)日：2013-10-24

    申请号：US13928522

    申请日：2013-06-27

    Applicant: AFFIBODY AB

    Inventor： Lars Abrahmsén ,  Nina Herne ,  Joachim Feldwisch ,  Christofer Lendel ,  Vladimir Tolmachev

    IPC: A61K51/08

    CPC classification number: A61K51/08 ,  A61K38/00 ,  A61K51/088 ,  C07K16/32

    Abstract: HER2 binding polypeptides comprising the amino acid sequence EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ wherein X1 in position 2 is M, I or L, and X2 in position 39 is S or C (SEQ ID NO:1) are disclosed. Moreover, such peptides comprising a chelating environment are disclosed. Also radiolabeled polypeptides formed by the peptides comprising a chelating environment and radionuclides are disclosed. Furthermore, methods of in vivo imaging of the body of a mammalian subject having or suspected of having a cancer characterized by overexpression of HER2 comprising administration of such a radiolabeled polypeptide followed by obtainment of an image of the body using a medical imaging instrument and also methods of treating such cancer are disclosed. Furthermore, the use of such a radiolabeled polypeptide in diagnosis and treatment of cancer characterized by overexpression of HER2. Nucleic acids encoding the polypeptides, expression vectors comprising the nucleic acids and host cells comprising the expression vectors are also disclosed.

    Abstract translation: HER2结合多肽包含氨基酸序列EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ，其中位置2中的X1是M，I或L，而位置39的X2是S或C（SEQ ID NO：1）。 此外，公开了包含螯合环境的这些肽。 还公开了由包含螯合环境和放射性核素的肽形成的放射性标记的多肽。 此外，具有或怀疑具有HER2过表达的哺乳动物受试者的身体的体内成像方法包括施用这种放射性标记的多肽，然后使用医学成像仪获得身体的图像，以及方法 公开了治疗这种癌症的方法。 此外，这种放射性标记的多肽在诊断和治疗HER2过表达的癌症中的应用。 还公开了编码多肽的核酸，包含核酸的表达载体和包含表达载体的宿主细胞。

    Polypeptide Libraries With A Predetermined Scaffold
    10.
    发明申请
    Polypeptide Libraries With A Predetermined Scaffold 审中-公开
    具有预定支架的多肽库

    公开(公告)号：US20170008936A1

    公开(公告)日：2017-01-12

    申请号：US15238184

    申请日：2016-08-16

    Applicant: Affibody AB

    Inventor： Lars Abrahmsén ,  Nina Herne ,  Christofer Lendel ,  Joachim Feldwisch

    IPC: C07K14/31 ,  G01N33/68 ,  C12N15/10

    Abstract: Populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ (SEQ ID NO: 1) or AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q (SEQ ID NO: 2), wherein each X individually corresponds to an amino acid residue which is varied in the population are disclosed. Also populations of polynucleotides, wherein each member encodes a member of a polypeptide population are disclosed. Furthermore, combinations of such polypeptide populations and such polynucleotide populations are disclosed, wherein each member of polypeptide population is physically or spatially associated with the polynucleotide encoding that member via means for genotype-phenotype coupling.

    Abstract translation: 基于共同支架的多肽变体群体，群体中的每个多肽包含支架氨基酸序列EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ（SEQ ID NO：1）或AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q（SEQ ID NO：2），其中每个 X分别对应于在群体中变化的氨基酸残基。 还公开了多核苷酸的种群，其中每个成员编码多肽群体的成员。 此外，公开了这种多肽群体和这种多核苷酸群体的组合，其中多肽群体的每个成员通过用于基因型 - 表型偶联的方式与编码该成员的多核苷酸物理或空间相关联。

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