公开(公告)号：US20150252079A1

公开(公告)日：2015-09-10

申请号：US14431336

申请日：2013-10-03

Applicant: AFFIBODY AB

Inventor： Magdalena Malm ,  John Löfblom ,  Stefan Ståhl

IPC: C07K14/00 ,  A61K51/08 ,  G01N33/574

CPC classification number: C07K14/00 ,  A61K51/088 ,  C07K14/71 ,  G01N33/57492 ,  G01N2333/71

Abstract: The present disclosure relates to polypeptides which bind to human epidermal growth factor receptor 3 (HER3) and to use of such polypeptides in imaging and therapy. The disclosure provides an HER3 binding polypeptide comprising a HER3 binding motif, which motif consists of the amino acid sequence EKYX4AYX7EIW X11LPNLTX17X18QX20 AAFIGX26 LX28D (SEQ ID NO:110)

Abstract translation: 本公开涉及结合人表皮生长因子受体3（HER3）的多肽以及在成像和治疗中使用这些多肽。 本公开提供了包含HER3结合基序的HER3结合多肽，该基序由氨基酸序列EKYX4AYX7EIW X11LPNLTX17X18QX20 AAFIGX26 LX28D（SEQ ID NO：110）

公开(公告)号：US09745350B2

公开(公告)日：2017-08-29

申请号：US14431336

申请日：2013-10-03

Applicant: AFFIBODY AB

Inventor： Magdalena Malm ,  John Löfblom ,  Stefan Ståhl

IPC: A61K51/08 ,  G01N33/574 ,  C07K14/00 ,  C07K14/71

CPC classification number: C07K14/00 ,  A61K51/088 ,  C07K14/71 ,  G01N33/57492 ,  G01N2333/71

Abstract: The present disclosure relates to polypeptides which bind to human epidermal growth factor receptor 3 (HER3) and to use of such polypeptides in imaging and therapy. The disclosure provides an HER3 binding polypeptide comprising a HER3 binding motif, which motif consists of the amino acid sequence EKYX4AYX7EIW X11LPNLTX17X18QX20 AAFIGX26 LX28D (SEQ ID NO:110).