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1.发明授权公开(公告)号：US09458238B2
公开(公告)日：2016-10-04
申请号：US14515892
申请日：2014-10-16
申请人： Affitech Research AS
发明人： Urs Beat Hagemann , Remko Albert Griep , Herald Reiersen , Sergej Michailovi{hacek over (c)} Kiprijanov
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/41 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/76 , G01N2333/7158
摘要： The present invention provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of macrophage-derived chemokine (MDC) and/or thymus and activation regulated chemokine (TARC) to CCR4. Also provided are inter alia immunoconjugates and compositions comprising such antibodies and methods and uses involving such antibodies, particularly in the medical and diagnostic fields.
摘要翻译： 本发明提供与人CC趋化因子受体4（CCR4）的细胞外结构域中的表位结合并且能够抑制巨噬细胞来源的趋化因子（MDC）和/或胸腺和活化调节的趋化因子（TARC）的结合的抗体， 到CCR4。 还提供了免疫缀合物和包含此类抗体的组合物，以及涉及此类抗体的方法和用途，特别是在医学和诊断领域。
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公开(公告)号：US20150104831A1
公开(公告)日：2015-04-16
申请号：US14515892
申请日：2014-10-16
申请人： AFFITECH RESEARCH AS
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/41 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/76 , G01N2333/7158
摘要： The present invention provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of macrophage-derived chemokine (MDC) and/or thymus and activation regulated chemokine (TARC) to CCR4. Also provided are inter alia immunoconjugates and compositions comprising such antibodies and methods and uses involving such antibodies, particularly in the medical and diagnostic fields.
摘要翻译： 本发明提供与人CC趋化因子受体4（CCR4）的细胞外结构域中的表位结合并且能够抑制巨噬细胞来源的趋化因子（MDC）和/或胸腺和活化调节的趋化因子（TARC）的结合的抗体， 到CCR4。 还提供了免疫缀合物和包含此类抗体的组合物，以及涉及此类抗体的方法和用途，特别是在医学和诊断领域。
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