公开(公告)号：US20220213189A1

公开(公告)日：2022-07-07

申请号：US17560232

申请日：2021-12-22

Applicant: Singapore Health Services PTE LTD ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Hau Wan Leung ,  Andre Boon Hwa CHOO ,  Mei Yee Vanessa DING ,  Shao Weng Daniel TAN ,  Narayanan Gopalakrishna IYER

IPC: C07K16/28 ,  A61P35/00 ,  G01N33/574 ,  A61K47/64 ,  A61K47/68 ,  C07K16/44 ,  A61K51/10 ,  C07K16/30

Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.

公开(公告)号：US20190177405A1

公开(公告)日：2019-06-13

申请号：US16321020

申请日：2017-07-26

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Simeon CUA ,  Andre Boon Hwa CHOO ,  Heng Liang TAN ,  Wey Jia FONG ,  Vanessa Mei Yee DING ,  Leonard Wen Yan LEONG

IPC: C07K16/18 ,  A61K39/395 ,  A61K31/282 ,  A61K31/337 ,  A61K31/5377 ,  A61K47/68 ,  C07K14/705 ,  A61K38/17

Abstract: The present invention relates to an antigen-binding protein, preferably a monoclonal antibody, against annexin A2 (ANXA2), comprising (i) a heavy chain variable domain comprising a VHCDR1 of sequence GYSITSGYSWH, a VHCDR2 of sequence YIHYSGSTKYNPSLKS and a VHCDR3 of sequence GSNYGFDY; and (ii) a light chain variable domain comprising a VLCDR1 of sequence KSSQSLLYSNDQKNYLA, a VLCDR2 of sequence WASIRES, and a VLCDR3 of sequence QQYYIYPLT. Also provided is an ANXA2 binding protein comprising (i) a heavy chain variable domain comprising a VHCDR1 of sequence VYSITSGYSWH; a VHCDR2 of sequence YIHYSGSTKYNPSLKS, and a VHCDR3 of sequence GTDNAVDY; and (ii) a light chain variable domain comprising a VLCDR1 of sequence KSSQSLLYSSNQKNYLA, a VLCDR2 of sequence WASSRES, and a VLCDR3 of sequence QQYYIYPLT. The antibodies preferably bind to an N-linked glycan on ANXA2, and are internalised upon binding. They may be conjugated with cytotoxins and may be used in the treatment or detection of cancer.

公开(公告)号：US20190233514A1

公开(公告)日：2019-08-01

申请号：US16341052

申请日：2017-10-10

Applicant: Singapore Health Services PTE LTD ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Hau Wan LEUNG ,  Andre Boon Hwa CHOO ,  Mei Yee vanessa DING ,  Shao Weng Daniel Tan ,  Narayanan Gopalakrishna Iyer

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  A61K47/64 ,  A61K47/68 ,  G01N33/574 ,  A61K51/10

CPC classification number: C07K16/2803 ,  A61K47/6415 ,  A61K47/6857 ,  A61K51/1048 ,  A61K2039/505 ,  A61K2039/55 ,  A61P35/00 ,  C07K16/30 ,  C07K16/44 ,  C07K2317/732 ,  G01N33/57473

Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.