公开(公告)号：US20220008358A1

公开(公告)日：2022-01-13

申请号：US17293362

申请日：2019-11-11

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Wai Leong TAM ,  Ser Yue LOO ,  Li Ping TOH

IPC: A61K31/07 ,  A61K45/06 ,  A61P35/04

Abstract: The present invention relates to a method of inducing mesenchymal-epithelial transition (MET) in a basal-like (or mesenchymal-like) cancer cell by contacting the cancer cell with an inducer of mesenchymal-epithelial transition for a time and under conditions sufficient to induce MET in the cell. Additionally, there is also provided a method of inhibiting epithelial-mesenchymal transition (EMT) of a cancer in a subject, the method comprising administering an inhibitor or regulator of lipid metabolism for a sufficient time and under conditions to inhibit epithelial mesenchymal transition (EMT) of the cancer in the subject.