公开(公告)号：US20180243441A1

公开(公告)日：2018-08-30

申请号：US15555482

申请日：2016-03-03

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Sheng-Hao CHAO

IPC: A61K47/69 ,  A61K38/04 ,  A61K47/68 ,  A61K47/66 ,  C07K14/47 ,  C07K7/08

CPC classification number: A61K47/6931 ,  A61K38/00 ,  A61K38/04 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/66 ,  A61K47/6851 ,  A61K2039/572 ,  A61K2300/00 ,  A61P3/04 ,  A61P35/00 ,  C07K7/08 ,  C07K14/00 ,  C07K14/4703

Abstract: Disclosed are isolated cytotoxic peptides having similar sequences as the basic region (BR) of Hexamethylene Bisacetamide Inducible Protein 1 (HEXIM1). Preferred embodiments include QLGKKKHRRRPSKKKRHW (SEQ ID No: 3). QLGRRRHRRRPSRRRRHW (SEQ ID No: 4) and QLGKKILAARPSKKKRHW (SEQ ID No: 5). Also encompassed are isolated nucleic acid molecules encoding for the claimed peptides, vectors comprising the isolated nucleic acids, compositions comprising peptides conjugated to cell-targeting or penetrating peptides or antibodies, nucleic acid molecules or vectors expressing conjugates thereof; methods of treating or preventing diseases or conditions, including cancers and obesity as well as a method of eliminating undifferentiated stem cells.