公开(公告)号：US20210223251A1

公开(公告)日：2021-07-22

申请号：US16761827

申请日：2018-12-06

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Jackie Y. Ying ,  Yiran Zheng ,  Yi Fei Lee

IPC: G01N33/574

Abstract: Disclosed herein are methods of (i) detecting cancer or cancer type in a subject or (ii) simultaneously testing for, or distinguishing between, multiple types of cancer in a subject; methods of screening subjects for a prevalence of cancer type or cancer types; methods of managing a subject with a cancer type; and methods of identifying whether a subject having a cancer type is responding to management of that cancer type; and methods of generating a response profile specific for a cancer type. Disclosed herein also include tumor-derived exosome-induced immune response or cancer-specific response profile created based on the measurement of functional impacts of tumor-derived exosomes on immune cells in vitro for use or when used for detecting or diagnosing cancer or cancer type in a subject; tumor-derived exosome-induced immune response for use in or when used for creating a cancer-specific response profile measuring functional impacts of tumor-derived exosomes on immune cells in vitro; and use of a tumor-derived exosome-induced immune response for generating a cancer-specific response profile measuring functional impacts of tumor-derived exosomes on immune cells in vitro. Disclosed herein also include tests, assays, kits, apparatus or devises for use or when used for the method, the response, the profile or the use as disclosed herein.