公开(公告)号：US10316078B2

公开(公告)日：2019-06-11

申请号：US15558937

申请日：2016-03-17

申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  National University of Singapore

发明人： Cheng-I Wang ,  Katja Fink ,  Paul Macary ,  Roland Zuest ,  Meihui Xu

IPC分类号： C07K16/10 ,  G01N33/569 ,  A61P31/12 ,  A61K39/00

摘要： Disclosed are isolated antibodies, or antigen binding fragments thereof, that bind to dengue virus epitopes, as well as kits containing them, compositions containing them, and passive vaccines comprising them, in one embodiment, the antibody or antigen binding fragment thereof is capable of binding to a whole dengue virus particle better than binding to a dengue virus surface glycoprotein. Also disclosed are methods of using the antibodies or antigen binding fragments thereof, nucleic acids encoding them, vectors expressing the nucleic acids, host producing them, and methods of manufacturing them.