公开(公告)号：US09974865B2

公开(公告)日：2018-05-22

申请号：US15065707

申请日：2016-03-09

申请人： AGENSYS, INC.

发明人： Christine Lowe ,  Nandini Rudra-Ganguly ,  Faisal Hayat Malik ,  Sung Ju Moon ,  Josh Snyder ,  Hector Avina ,  Cyrus Virata ,  Linnette Capo ,  Gao Liu

IPC分类号： A61K39/395 ,  A61K47/48 ,  A61K45/06 ,  C07K16/28 ,  A61K47/68 ,  A61K39/00

CPC分类号： A61K47/6803 ,  A61K45/06 ,  A61K47/6811 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732

摘要： Antibody drug conjugates (ADC's) that bind to FLT3 protein and variants thereof are described herein. FLT3 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.

公开(公告)号：US20160272716A1

公开(公告)日：2016-09-22

申请号：US15065707

申请日：2016-03-09

申请人： AGENSYS, INC.

发明人： Christine Lowe ,  Nandini Rudra-Ganguly ,  Faisal Hayat Malik ,  Sung Ju Moon ,  Josh Snyder ,  Hector Avina ,  Cyrus Virata ,  Linnette Capo ,  Gao Liu

IPC分类号： C07K16/28 ,  A61K45/06 ,  A61K47/48

CPC分类号： A61K47/6803 ,  A61K45/06 ,  A61K47/6811 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732

摘要： Antibody drug conjugates (ADC's) that bind to FLT3 protein and variants thereof are described herein. FLT3 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.

摘要翻译： 本文描述了结合FLT3蛋白及其变体的抗体药物偶联物（ADC）。 FLT3在正常成人组织中表现出明显且有限的表达模式，并且在表I中列出的癌症中异常表达。因此，本发明的ADC提供了用于治疗癌症的治疗组合物。

公开(公告)号：US10751422B2

公开(公告)日：2020-08-25

申请号：US15556587

申请日：2016-03-09

申请人： AGENSYS, INC.

发明人： Nandini Rudra-Ganguly ,  Christine Lowe ,  Faisal Hayat Malik ,  Sung Ju Moon ,  Josh Snyder ,  Hector Avina ,  Cyrus Virata ,  Linnette Capo ,  Gao Liu

IPC分类号： A61K45/06 ,  A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

摘要： Antibody drug conjugates (ADC's) that bind to FLT3 protein and variants thereof are described herein. FLT3 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.