公开(公告)号：US20230210982A1

公开(公告)日：2023-07-06

申请号：US18061045

申请日：2022-12-02

Applicant: AIVITA BIOMEDICAL, INC

Inventor： Gabriel NISTOR ,  Hans KIERSTEAD ,  Robert O. DILLMAN

IPC: A61K39/215 ,  C12N5/0784

CPC classification number: A61K39/215 ,  C12N5/0639 ,  C12N2501/2304 ,  C12N2501/22 ,  C12N2501/2302 ,  C12N2501/24 ,  A61K2039/5154

Abstract: Disclosed herein is a kit to produce a personalized vaccine based on autologous dendritic cells. The kit contains all the materials, reagents and information necessary to produce a dose of live dendritic cell vaccine against a pathogen organism, part of a pathogen organism, a toxin, a venom, a structure obtained by recombinant method or chemical synthesis.

公开(公告)号：US20220347277A1

公开(公告)日：2022-11-03

申请号：US17698608

申请日：2022-03-18

Applicant: AIVITA BIOMEDICAL, INC.

Inventor： Gabriel NISTOR ,  Andrew N. CORNFORTH ,  Robert O. DILLMAN

IPC: A61K39/00 ,  A61K35/15 ,  C12N5/0784 ,  C12N5/09

Abstract: The present specification provides methods for augmenting the antigenic content, especially of tumor-associated antigens (TAA), and immunogenicity of cancer cells; methods for enhancing cross-presentation in dendritic cells, compositions comprising such manipulated cells derived from single cancer patients; and methods of using those compositions as a personal immunotherapeutic product to treat the donor patient's cancer.