公开(公告)号：US12240892B2

公开(公告)日：2025-03-04

申请号：US17113630

申请日：2020-12-07

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Sang Myun Park ,  Yu Ree Choi ,  Jae Bong Kim

IPC: C07K16/18 ,  A61K39/00 ,  A61P25/28 ,  C12N15/113

Abstract: A composition including a substance that inhibits an expression or activity of c-src and its use in inhibiting aggregation and/or migration of α-syn are disclosed. The composition may be a pharmaceutical composition and can be used for preventing or treating synucleinopathy. The substance can inhibit the signal transduction induced by α-syn migrating to adjacent cells, thus mitigating the cytotoxic influence of α-syn on the adjacent cells; and can inhibit the denaturation of monomeric α-syn into aggregated α-syn, which may be a major cause of synucleinopathy, and thus, can be beneficially used as a therapeutic agent for synucleinopathy.