公开(公告)号：US20220168261A1

公开(公告)日：2022-06-02

申请号：US17430849

申请日：2020-02-14

申请人： AKAMARA THERAPEUTICS, INC.

发明人： Heena AGGARWAL ,  Shweta CHAUBEY ,  Rajat DESIKAN ,  Nimish GUPTA ,  Sonia JAIN ,  Seema MITTAL ,  Shiladitya SENGUPTA

IPC分类号： A61K31/282 ,  A61P35/00

摘要： The present disclosure relates to methods of managing cancer by modulating/inhibiting cap methyltransferase enzyme. The modulation/inhibition is carried out by pharmacological or biological inhibitors, including but not limited to compounds of formula (VIII) or Compound A or A-1. Thus, the present disclosure relates to such inhibitors including compounds of formula (VIII) and their use for management of cancer. In some aspects, the compound of formula (VIII) is Compound 1. The present disclosure also relates to methods of activating B cells or T cells via modulation of cap methyltransferases. The present disclosure also relates to methods of managing cancer with a molecule or biologic that generates unmethylated RNA. The generation of unmethylated RNA activates B cells and presents the RNA to B-cell receptor (BCR). The present disclosure therefore also relates to management of cancer by activating B cells and then adoptively transferring the B cells to exert an anticancer effect.