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公开(公告)号:US20120107827A1
公开(公告)日:2012-05-03
申请号:US13271614
申请日:2011-10-12
申请人: ALBERT K. TAI , CHUNYAN SONG , MICHAEL MARTIN OLLMANN , LUCILE A. GILLETT , JOANNE I. ADAMKEWICZ , KIM LICKTEIG
发明人: ALBERT K. TAI , CHUNYAN SONG , MICHAEL MARTIN OLLMANN , LUCILE A. GILLETT , JOANNE I. ADAMKEWICZ , KIM LICKTEIG
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6883 , C12Q2600/158 , G01N33/57496 , G01N2333/4736
摘要: Human PSMC genes are identified as modulators of the RB pathway, and thus are therapeutic targets for disorders associated with defective RB function. Methods for identifying modulators of RB, comprising screening for agents that modulate the activity of PSMC are provided.
摘要翻译: 人类PSMC基因被鉴定为RB途径的调节剂,因此是与缺陷型RB功能相关的疾病的治疗靶点。 提供了用于鉴定RB调节剂的方法,包括筛选调节PSMC活性的试剂。