公开(公告)号：US20240383997A1

公开(公告)日：2024-11-21

申请号：US18621575

申请日：2024-03-29

Applicant: ALECTOR LLC

Inventor： Eric BROWN ,  Hamid SALIMI ,  Wei-Hsien HO ,  Leonard PRESTA ,  Margaret TANG ,  Jeonghoon SUN

IPC: C07K16/28 ,  A61K49/00 ,  C07K16/18 ,  G01N33/50

Abstract: Provided herein are engineered constant domains that have been engineered to comprise a blood brain barrier (BBB)-binding region, such a CDRH3 from an antibody that binds to a blood brain barrier target. Such engineered constant domains can be within a full length antibody or an antigen-binding fragment of an antibody such that the antibody or fragment is capable of binding to both the antigen of the antibody or fragment and the BBB target and is capable of being transported across the BBB.