专利检索 ap:("ALLOGENE THERAPEUTICS, INC." OR "PFIZER INC.") AND inv:"Yi Zhang" 第 1 页

1.

发明授权
DLL3 targeting chimeric antigen receptors and binding agents 有权

公开(公告)号：US11673953B2

公开(公告)日：2023-06-13

申请号：US16802822

申请日：2020-02-27

申请人： ALLOGENE THERAPEUTICS, INC. , PFIZER INC.

发明人： Yi Zhang , Thomas John Van Blarcom , Siler Panowski , Silvia K. Tacheva-Grigorova , Barbra Johnson Sasu

IPC分类号： C07K16/28 , A61P35/00 , A61K39/00 , C12N15/63

CPC分类号： C07K16/2809 , A61P35/00 , C07K16/2887 , C12N15/63 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2319/70

摘要： Provided herein are DLL3 binding agents and chimeric antigen receptors (CARs) comprising a DLL3 binding molecule that specifically binds to DLL3; and immune cells comprising these DLL3-specific CARs, e.g., CAR-T cells. Also provided are methods of making and using DLL3-specific CARs, and immune cells comprising DLL3-specific CARs.