公开(公告)号：US20210220368A1

公开(公告)日：2021-07-22

申请号：US16309808

申请日：2017-06-15

Applicant: Almirall, S.A.

Inventor： Bernat Vidal Juan ,  Maria Victoria Revilla Sanchez ,  Gema Tarrason Encuentra

IPC: A61K31/5377 ,  A61P17/00 ,  A61K9/00 ,  A61K9/06

Abstract: The present invention relates to the use of timolol in treating rosacea, and to pharmaceutical compositions comprising timolol.

公开(公告)号：US20230235040A1

公开(公告)日：2023-07-27

申请号：US18002882

申请日：2021-06-21

Applicant: Almirall, S.A.

Inventor： Thomas Huber ,  Vicente Marco Garcia Gonzalez ,  Bernat Vidal Juan ,  Germaine Fuh-Kelly ,  Yao-ming Huang

IPC: C07K16/24

CPC classification number: C07K16/244 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/92 ,  C07K2317/76

Abstract: The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human IL-36 cytokines, IL-36α, IL-36β, and/or IL-36γ, and block the IL-36 stimulated signaling pathways. Compositions comprising such binding proteins and methods of making and using such binding proteins are also provided.

公开(公告)号：US10759793B2

公开(公告)日：2020-09-01

申请号：US15735235

申请日：2016-06-10

Applicant: ALMIRALL, S.A.

Inventor： Cristina Esteve Trias ,  Joan Taltavull Moll ,  Jacob Gonzalez Rodriguez ,  Bernat Vidal Juan

IPC: C07D471/04 ,  C07D239/24

Abstract: New 2-(pyrazolopyridin-3-yl)pyrimidine derivatives are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy as inhibitors of Janus Kinases (JAK).