公开(公告)号：US20190233815A1

公开(公告)日：2019-08-01

申请号：US16216628

申请日：2018-12-11

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Donna T. Ward ,  Jason Rhodes

IPC分类号： C12N15/113 ,  A01N25/00 ,  C12N15/85 ,  A01N57/16 ,  C12N15/86 ,  A01K67/033

CPC分类号： C12N15/113 ,  A01K67/0333 ,  A01N25/002 ,  A01N57/16 ,  A61K48/00 ,  C12N15/1131 ,  C12N15/85 ,  C12N15/86 ,  C12N2310/14 ,  C12N2320/00 ,  C12N2320/30 ,  C12N2320/32 ,  C12N2710/14043

摘要： Provided herein are methods and compositions for modulating gene expression in insects by administering a composition comprising an RNA effector molecule and a delivery agent. Methods are provided for controlling pest populations by inhibiting insect growth, development, survival, reproduction and/or viability. Also provided herein are methods for treating or preventing disease in an insect caused by a pathogen or by external factors (e.g., pollution, environment, stress, weather, etc.).

公开(公告)号：US10190118B2

公开(公告)日：2019-01-29

申请号：US15330843

申请日：2016-11-07

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Donna T. Ward ,  Jason Rhodes

IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K48/00 ,  C12N15/113 ,  A01K67/033 ,  C12N15/85 ,  A01N25/00 ,  A01N57/16 ,  C12N15/86

摘要： Provided herein are methods and compositions for modulating gene expression in insects by administering a composition comprising an RNA effector molecule and a delivery agent. Methods are provided for controlling pest populations by inhibiting insect growth, development, survival, reproduction and/or viability. Also provided herein are methods for treating or preventing disease in an insect caused by a pathogen or by external factors (e.g., pollution, environment, stress, weather, etc.).

公开(公告)号：US20170204411A1

公开(公告)日：2017-07-20

申请号：US15330843

申请日：2016-11-07

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Donna T. Ward ,  Jason Rhodes

IPC分类号： C12N15/113 ,  A01N25/00 ,  C12N15/86 ,  A01N57/16

CPC分类号： C12N15/113 ,  A01K67/0333 ,  A01N25/002 ,  A01N57/16 ,  A61K48/00 ,  C12N15/1131 ,  C12N15/85 ,  C12N15/86 ,  C12N2310/14 ,  C12N2320/00 ,  C12N2320/30 ,  C12N2320/32 ,  C12N2710/14043

摘要： Provided herein are methods and compositions for modulating gene expression in insects by administering a composition comprising an RNA effector molecule and a delivery agent. Methods are provided for controlling pest populations by inhibiting insect growth, development, survival, reproduction and/or viability. Also provided herein are methods for treating or preventing disease in an insect caused by a pathogen or by external factors (e.g., pollution, environment, stress, weather, etc.).