专利检索 ap:("ALNYLAM PHARMACEUTICALS, INC.") AND inv:"STEPHEN ABBOTT" 第 1 页

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发明公开
MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开

公开(公告)号：US20240254487A1

公开(公告)日：2024-08-01

申请号：US18532300

申请日：2023-12-07

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： JONATHAN EDWARD FARLEY , MARK K. SCHLEGEL , JAMES D. MCININCH , JEFFREY ZUBER , ADAM CASTORENO , STEPHEN ABBOTT , JOSEPH BARRY

IPC分类号： C12N15/113 , A61K48/00 , C12N15/85

CPC分类号： C12N15/113 , A61K48/005 , C12N15/85 , C12N2310/14 , C12N2310/315

摘要： The disclosure relates to double stranded ribonucleic acid interference (dsRNAi) agents and compositions targeting a microtubule-associated protein tau (MAPT) gene, as well as methods of inhibiting expression of a MAPT gene and methods of treating subjects having a MAPT-associated disease or disorder, e.g., Alzheimer's disease, frontotemporal dementia, progressive supranuclear palsy, or other tauopathies, using such dsRNAi agents and compositions.