公开(公告)号：US3462459A

公开(公告)日：1969-08-19

申请号：US3462459D

申请日：1967-05-12

Applicant: AMERICAN HOME PROD

Inventor： JEN TIMOTHY Y ,  HUGHES GORDON A ,  SMITH HERCHEL

IPC: C07C45/00 ,  C07D311/16 ,  C07D7/28

CPC classification number: C07D311/16 ,  C07C45/00 ,  C07C47/565

公开(公告)号：US3576887A

公开(公告)日：1971-04-27

申请号：US3576887D

申请日：1967-05-01

Applicant: AMERICAN HOME PROD

Inventor： HUGHES GORDON A ,  JEN TIMOTHY Y ,  SMITH HERCHEL

IPC: C07C39/23 ,  C07D311/80 ,  C07C37/00 ,  C07C39/02

CPC classification number: C07C39/23 ,  C07C2601/16 ,  C07D311/80

Abstract: 6,6-DIALKYLTETRA-HYDRO- AND HEXAHYDRO-6H-DIBENZO (B,D) PYRANS (I) ARE OBTAINED BY CYCLODEHYDRATING A 1-(1''-HYDROXY)ALKYL-2-O-HYDROXYPHENYLCYCLOHEXANE OR -ONE (III). COMPOUNDS (III) ARE OBTAINED BY TREATING A 2-O-ALKOXY-PHENYLCYCLOHEXANE- OR ENECARBOXYLIC ACID OR ESTER (II) WITH A GRIGNARD REAGENT. ENANTIOMORPHIC COMPOUNDS (I), PARTICULARLY, (-) -$8-TETRAHYDROCANNABINOL, A BIOLOGICALLY ACTIVE, ASYMMETRIC CONSTITUENT OF HASHISH, ARE PREPARED BY CYCLIZING THE CORRESPONDING ENANTIOMORPHIC COMPOUNDS (III).

公开(公告)号：US3467676A

公开(公告)日：1969-09-16

申请号：US3467676D

申请日：1967-04-05

Applicant: AMERICAN HOME PROD

Inventor： JEN TIMOTHY Y ,  HUGHES GORDON A ,  SMITH HERCHEL

IPC: C07D311/22 ,  C07F1/02 ,  C07D7/26 ,  C07F1/06

CPC classification number: C07D311/22