公开(公告)号：US3912725A

公开(公告)日：1975-10-14

申请号：US47675774

申请日：1974-06-05

Applicant: AMERICAN HOME PROD

Inventor： LEEMING MICHAEL R G ,  STRIKE DONALD P ,  KAO WEN-LING

IPC: C07C405/00 ,  C07D309/06 ,  C07C69/02 ,  C07D309/22

CPC classification number: C07C405/00

Abstract: A process for the conversion of A type prostaglandins to E type prostaglandins is disclosed. Heretofore unknown prostaglandin derivatives are utilized as intermediates in the process.

Abstract translation: 公开了将A型前列腺素转化为E型前列腺素的方法。 迄今未知的前列腺素衍生物在该过程中被用作中间体。

公开(公告)号：US3928134A

公开(公告)日：1975-12-23

申请号：US51712674

申请日：1974-10-23

Applicant: AMERICAN HOME PROD

Inventor： GREENSPAN GEORGE ,  LEEMING MICHAEL R G

IPC: C07C405/00 ,  C12P31/00 ,  C12D1/02

CPC classification number: C12P31/00 ,  C07C405/00 ,  Y10S435/911

Abstract: Reduction of 7-(2-((3R)-3-hydroxy-1-octenyl)-5-oxo-3cyclopenten-1-yl)-5-heptenoic acid, and its methyl ester, acetate by fungi of the genera Corynespora is disclosed. The product 7(2-((3R)-3-hydroxy-1-octenyl)-5-oxo-cyclopentyl)-5-heptenoic acid(11-deoxy-15-epi-PGE2), which is novel, is useful as an intermediate for the synthesis of other physiologically active prostaglandins.

Abstract translation: 由属的真菌还原7-（2 - [（3R）-3-羟基-1-辛烯基] -5-氧代-3-环戊烯-1-基）-5-庚烯酸及其甲酯，乙酸酯 披露了蜡碱菌属。 新颖的7-（2 - [（3R）-3-羟基-1-辛烯基] -5-氧代 - 环戊基）-5-庚烯酸（11-脱氧-15-表 - PGE2）是有用的 作为合成其他生理活性前列腺素的中间体。