公开(公告)号：US20230040604A1

公开(公告)日：2023-02-09

申请号：US17786375

申请日：2020-12-17

Applicant: AMGEN INC.

Inventor： Ashutosh CHAUDHRY ,  Wenjun OUYANG

IPC: C07K14/55 ,  C07K16/28 ,  C07K14/525 ,  C12N15/62 ,  C12N5/0783 ,  A61P37/06 ,  A61P37/04 ,  C12N15/85 ,  A61K47/64

Abstract: Provided herein are combinations of an IL-2 molecule or mutein and a TNFR agonist, and complexes comprising IL-2/TNFR agonist molecules, such as Fc-bound IL-2/TNFR agonist molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are methods of making and using the compositions of the present invention.