公开(公告)号：US20230203198A1

公开(公告)日：2023-06-29

申请号：US17928577

申请日：2021-06-03

Applicant: AMGEN INC.

Inventor： Pavan Ghattyvenkatakrishna ,  Brendan Amer

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/30 ,  A61P35/00 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/468 ,  C07K16/2809 ,  C07K16/28 ,  C07K16/30 ,  A61P35/00 ,  A61K45/06 ,  A61K39/3955 ,  C07K2317/31 ,  C07K2319/02 ,  C07K2317/622

Abstract: New formats of bispecific binding constructs are described that bind to a target antigen and to a CD3 molecule on an effector cell, as well as their methods of making Additionally, uses in therapeutic indications are also described.