公开(公告)号：US20190167682A1

公开(公告)日：2019-06-06

申请号：US16319783

申请日：2017-07-20

Applicant: AMGEN INC.

Inventor： Matthew WEISS ,  John R. BUTLER ,  Benjamin Charles MILGRAM ,  Gwenaella RESCOURIO ,  Alessandro BOEZIO ,  Brian Andrew SPARLING ,  Daniel LA

IPC: A61K31/506 ,  A61P25/00 ,  A61K31/4439

CPC classification number: A61K31/506 ,  A61K31/4439 ,  A61P25/00 ,  C07D213/75 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The present invention provides compounds of Formula (I), as defined in the specification, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders, cough, or itch. Also provided are pharmaceutical compositions containing compounds of the present invention.