公开(公告)号：US20240084301A1

公开(公告)日：2024-03-14

申请号：US18357495

申请日：2023-07-24

Applicant: AMGEN INC.

Inventor： Elizabeth Ann KILLION ,  Jerry Ryan HOLDER ,  Bryan MEADE ,  Justin K. MURRAY ,  Oliver R. HOMANN ,  Briana Renee GRIEGO ,  Murielle Marie VENIANT ELLISON

IPC: C12N15/113 ,  A61P1/16 ,  A61P3/04

CPC classification number: C12N15/113 ,  A61P1/16 ,  A61P3/04 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322

Abstract: The present application relates to compositions and methods for modulating expression of Family with Sequence Similarity 13 Member A (FAM13A) protein. In particular, the present application relates to nucleic acid-based therapeutics for reducing FAM13A gene expression via RNA interference and methods of using such nucleic acid-based therapeutics to reduce abdominal adiposity, reduce body weight, reduce fat mass, improve metabolic parameters including insulin resistance and non-alcoholic steatohepatitis (NASH), and reduce risk of myocardial infarction.