公开(公告)号：US20150087819A1

公开(公告)日：2015-03-26

申请号：US14562546

申请日：2014-12-05

Applicant: AMGEN INC.

Inventor： SIMON MARK JACKSON ,  NIGEL PELHAM CLINTON WALKER ,  DEREK EVAN PIPER ,  BEI SHAN ,  WENYAN SHEN ,  JOYCE CHI YEE CHAN ,  CHADWICK TERENCE KING ,  RANDAL ROBERT KETCHEM ,  CHRISTOPHER MEHLIN ,  TERESA ARAZAS CARABEO ,  QIONG CAO

IPC: C07K16/40

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.