公开(公告)号：US20230381276A1

公开(公告)日：2023-11-30

申请号：US18072959

申请日：2022-12-01

Applicant: AMGEN INC.

Inventor： Khaled M.K.Z. ALI ,  Neeraj Jagdish AGRAWAL ,  Gunasekaran KANNAN ,  Ian FOLTZ ,  Zhulun WANG ,  Darren BATES ,  Marissa MOCK ,  Shunsuke TAKENAKA

IPC: A61K38/20 ,  C12N15/63 ,  A61P35/00 ,  C07K16/28 ,  C07K14/54 ,  A61K47/68

CPC classification number: A61K38/20 ,  C12N15/63 ,  A61P35/00 ,  C07K16/283 ,  C07K14/54 ,  A61K47/6849 ,  A61K47/6813 ,  C12N2740/10041

Abstract: Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.