公开(公告)号：US20190300507A1

公开(公告)日：2019-10-03

申请号：US16347970

申请日：2017-11-03

Applicant: AMGEN INC.

Inventor： Yinhong CHEN ,  Alan C. CHENG ,  Mikkel V. DEBENEDETTO ,  Paul John DRANSFIELD ,  James S. HARVEY ,  Jonathan HOUZE ,  Aarif Yusuf KHAKOO ,  Su-Jen LAI ,  Zhihua MA ,  Vatee PATTAROPONG ,  Gayathri SWAMINATH ,  Charles KREIMAN ,  David C. MOEBIUS ,  Ankit SHARMA

IPC: C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D413/14 ,  A61P9/04

Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, I or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the structures where the definitions of the variables are provided herein.