公开(公告)号：US20210171529A1

公开(公告)日：2021-06-10

申请号：US17103350

申请日：2020-11-24

Applicant: Amgen Inc.

Inventor： Jennifer R. ALLEN ,  Albert AMEGADZIE ,  Matthew P. BOURBEAU ,  Ning CHEN ,  Clifford GOODMAN ,  Giulia LATTANZI ,  Iain LINGARD ,  Qingyian LIU ,  Jonathan D. LOW ,  Vu Van MA ,  Ana E. MINATTI ,  Alfonso POZZAN ,  Corey REEVES ,  Aaron C. SIEGMUND ,  Sabrina TASSINI ,  Federica TONELLI ,  Mary WALTON

IPC: C07D487/04 ,  A61P3/04 ,  C07D471/04 ,  C07D498/04

Abstract: The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5D”). The compounds have a general Formula 1: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

公开(公告)号：US20210188874A1

公开(公告)日：2021-06-24

申请号：US17103389

申请日：2020-11-24

Applicant: Amgen Inc.

Inventor： Jennifer R. ALLEN ,  Michela BELTRANI ,  Matthew P. BOURBEAU ,  Teodora P. DAMYANOVA ,  Iain LINGARD ,  Ana E. MINATTI ,  Paolo VINCETTI

IPC: C07D513/04 ,  C07D487/04 ,  C07D498/04 ,  A61P3/04

Abstract: The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5D”). The compounds have a general Formula I wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

公开(公告)号：US20230159560A1

公开(公告)日：2023-05-25

申请号：US18056863

申请日：2022-11-18

Applicant: AMGEN INC.

Inventor： Jennifer R. ALLEN ,  Michela BELTRANI ,  Matthew P. BOURBEAU ,  Teodora P. DAMYANOVA ,  Iain LINGARD ,  Ana E. MINATTI ,  Paolo Vincetti

IPC: C07D513/04 ,  A61P3/04 ,  C07D487/04 ,  C07D498/04

CPC classification number: C07D513/04 ,  A61P3/04 ,  C07D487/04 ,  C07D498/04

Abstract: The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5D”). The compounds have a general Formula I.




wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

公开(公告)号：US20210221824A1

公开(公告)日：2021-07-22

申请号：US17203457

申请日：2021-03-16

Applicant: Amgen Inc.

Inventor： Jennifer R. ALLEN ,  Michela BELTRANI ,  Matthew P. BOURBEAU ,  Teodora P. DAMYANOVA ,  Iain LINGARD ,  Ana E. MINATTI ,  Paolo VINCETTI

IPC: C07D513/04 ,  C07D487/04 ,  C07D498/04 ,  A61P3/04

Abstract: The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5D”). The compounds have a general Formula I wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.