公开(公告)号：US20220281966A1

公开(公告)日：2022-09-08

申请号：US17630437

申请日：2020-07-24

Applicant: AMGEN INC.

Inventor： Agnieszka KIELCZEWSKA ,  Ian Nevin FOLTZ ,  Palaniswami RATHANASWAMI ,  Maria Sheena AMADOR ,  Bram ESTES ,  Igor D'ANGELO

IPC: C07K16/24 ,  A61P11/00 ,  A61P11/08 ,  A61P11/06 ,  A61P17/00

Abstract: The present invention is related to antibodies directed to IL-13 and uses of such antibodies. For example, in accordance with the present invention, there are provided human monoclonal antibodies directed to IL-13. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Additionally, methods of using these antibodies to treat patients are also provided.

公开(公告)号：US20220017636A1

公开(公告)日：2022-01-20

申请号：US17323884

申请日：2021-05-18

Applicant: Amgen Inc. ,  Amgen Research (Munich) GmbH ,  Immatics Biotechnologies GmbH

Inventor： Ian Nevin FOLTZ ,  Weihsu Claire CHEN ,  Lars GAEDTKE ,  Susmith MUKUND ,  Tobias RAUM ,  Heiko SCHUSTER ,  Kristin TARBELL ,  Derek E. PIPER ,  Johannes BROZY ,  Markus MUENZ ,  Igor D'ANGELO

IPC: C07K16/30 ,  C07K16/28 ,  A61P35/00

Abstract: The present invention relates to antibody constructs comprising a domain which binds to a MAGEB2 peptide complexed with an HLA and optionally, another domain which binds to CD3. Moreover, the invention provides polynucleotides encoding the antibody constructs, vectors comprising said polynucleotides and host cells transformed or transfected with said polynucleotides or vectors. Furthermore, the invention provides processes for producing the antibody constructs of the invention, medical uses of said antibody constructs, and kits comprising said antibody constructs.