公开(公告)号：US11807634B2

公开(公告)日：2023-11-07

申请号：US17344939

申请日：2021-06-10

Applicant: AMGEN INC.

Inventor： Benjamin C Milgram ,  Isaac E Marx ,  John Stellwagen ,  Wei Zhao ,  Alan H. Cherney

IPC: C07D413/12

CPC classification number: C07D413/12

Abstract: The present invention provides a compound of Formula (I):






an enantiomer, diastereoisomer, atropisomer thereof, a mixture thereof, or a pharmaceutically acceptable salt thereof, that inhibits voltage-gated sodium channels, in particular NaV1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders, cough, and itch. Also provided are pharmaceutical compositions containing the compounds of the present invention. Also further provided is an atropi-selective preparation of said compounds of Formula (I), and intermediate thereof.

公开(公告)号：US12240839B2

公开(公告)日：2025-03-04

申请号：US17633151

申请日：2021-06-10

Applicant: AMGEN INC.

Inventor： Benjamin C Milgram ,  Isaac E Marx ,  Haoxuan Wang ,  Alan H Cherney

IPC: C07D413/12 ,  A61P25/04 ,  C07D215/36 ,  C07D401/12

Abstract: The present invention provides a cyclobutyl dihydroquinoline sulfonamide compound of Formula (I), an enantiomer, diastereoisomer, atropisomer thereof, a mixture thereof, or a pharmaceutically acceptable salt thereof, that inhibits voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders, cough, and itch. Also provided are pharmaceutical compositions containing the compounds of the present invention. Also further provided is an atropi-selective preparation of said compounds of Formula (I), and intermediate thereof.