公开(公告)号：US20250059205A1

公开(公告)日：2025-02-20

申请号：US18696946

申请日：2022-04-28

Applicant: AMGEN INC.

Inventor： Brian Alan Lanman ,  Ryan Paul Wurz ,  Wei Zhao ,  Xiaofen Li ,  Michael M. Yamano ,  Yunxiao Li ,  Ning Chen ,  Birgitte Weinreich Husemoen ,  Sebastian Leth-Petersen ,  Jose M. Medina ,  Kexue Li ,  Liping Pettus ,  Rene Rahimoff ,  Primali Vasundera Navaratne ,  Huan Rui ,  Christopher P. Mohr

IPC: C07D519/00 ,  A61K31/4995 ,  A61K31/517 ,  C07D487/08

Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.