公开(公告)号：US11274105B2

公开(公告)日：2022-03-15

申请号：US16977527

申请日：2019-03-04

Applicant: AMGEN INC.

Inventor： Gwenaella Rescourio ,  Ana Gonzalez Buenrostro ,  Sean P. Brown ,  Mike Lizarzaburu ,  Julio Medina ,  Salman Yojiro Jabri ,  Daqing Sun ,  Scott Preston Simonovich ,  Xuelei Yan ,  Yihong Li ,  Yosup Rew

IPC: C07D498/22 ,  C07D498/10 ,  C07D498/20 ,  C07D519/00 ,  A61K31/635 ,  A61K31/7068 ,  A61K38/07

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.