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公开(公告)号：US11919964B2
公开(公告)日：2024-03-05
申请号：US17005202
申请日：2020-08-27
Applicant: AMGEN INC.
Inventor： Gunasekaran Kannan , Ling Liu , Edward J. Belouski , Cen Xu
CPC classification number: C07K16/2869 , C07K16/18 , C07K16/28 , C07K2317/31 , C07K2317/35 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/70 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to bispecific antigen binding proteins that are capable of binding to both the human CGRP receptor and the human PAC1 receptor. Pharmaceutical compositions comprising the bispecific antigen binding proteins as well as methods for producing them are also disclosed. Methods of using the bispecific antigen binding proteins to ameliorate or treat conditions associated with the two receptors, such as chronic pain, migraine, and cluster headache, are also described.
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公开(公告)号：US10934362B2
公开(公告)日：2021-03-02
申请号：US15511176
申请日：2015-09-15
Applicant: AMGEN INC.
Inventor： Gunasekaran Kannan , Ling Liu , Edward J. Belouski , Cen Xu
Abstract: The present invention relates to bispecific antigen binding proteins that are capable of binding to both the human CGRP receptor and the human PAC1 receptor. Pharmaceutical compositions comprising the bispecific antigen binding proteins as well as methods for producing them are also disclosed. Methods of using the bispecific antigen binding proteins to ameliorate or treat conditions associated with the two receptors, such as chronic pain, migraine, and cluster headache, are also described.
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