公开(公告)号：US12054476B2

公开(公告)日：2024-08-06

申请号：US17551105

申请日：2021-12-14

申请人： AMGEN INC.

发明人： Nuria A. Tamayo ,  Abhisek Banerjee ,  James Alexander Brown ,  Michael J Frohn ,  Jian Jeffrey Chen ,  Kexue Li ,  Qingyian Liu ,  Jonathan Dante Low ,  Vu Ma ,  Liping H. Pettus ,  Mary Catherine Walton ,  Ana Elena Minatti ,  Matthew Paul Bourbeau ,  Lei Jia

IPC分类号： C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D419/14 ,  C07D491/107

CPC分类号： C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D419/14 ,  C07D491/107

摘要： Compounds of formula (I):




as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.