公开(公告)号：US20200376131A1

公开(公告)日：2020-12-03

申请号：US16857111

申请日：2020-04-23

Applicant: AMGEN INC.

Inventor： Gary LUEHR ,  Shabbir T. ANIK ,  Ge PENG ,  Irina DOTSENKO ,  Pasit PHIASIVONGSA ,  Dante ROMANINI

IPC: A61K47/60 ,  C07D405/12 ,  A61K9/00 ,  A61K38/07 ,  C08G65/333

Abstract: The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.

公开(公告)号：US20170340746A1

公开(公告)日：2017-11-30

申请号：US15602823

申请日：2017-05-23

Applicant: AMGEN INC.

Inventor： Gary LUEHR ,  Shabbir T. ANIK ,  Ge PENG ,  Irina DOTSENKO ,  Pasit PHIASIVONGSA ,  Dante ROMANINI

IPC: A61K47/60 ,  C08G65/333 ,  A61K9/00 ,  A61K38/07

Abstract: The present invention provides polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein. The invention also provides methods of making and using these compounds to treat cancer, and particularly to treat hematological malignancies including multiple myeloma.

公开(公告)号：US20200069808A1

公开(公告)日：2020-03-05

申请号：US16675134

申请日：2019-11-05

Applicant: AMGEN INC.

Inventor： Gary LUEHR ,  Shabbir T. ANIK ,  Ge PENG ,  Irina DOTSENKO ,  Pasit PHIASIVONGSA ,  Dante ROMANINI

IPC: A61K47/60 ,  A61K9/00 ,  A61K38/07 ,  C08G65/333 ,  C07D405/12

Abstract: The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.