公开(公告)号：US20200048367A1

公开(公告)日：2020-02-13

申请号：US16607673

申请日：2018-04-27

Applicant: AMGEN INC.

Inventor： Neeraj Jagdish AGRAWAL ,  Pavan GHATTYVENKATAKRISHNA ,  Sekhar KANAPURAM ,  Christopher James SLOEY

IPC: C07K16/40 ,  A61K38/05 ,  A61K31/198 ,  A61K31/4172 ,  A61K31/401 ,  A61K47/26 ,  A61K9/08 ,  A61K9/19

Abstract: Provided herein are excipients capable of effectively reducing the viscosity of polypeptide (e.g., therapeutic polypeptide) formulations. The viscosity reducing excipients are dipeptides containing arginine at the carboxy terminus and N-acetylated serine or N-acetylated proline at the N-terminus. Glutamate-arginine is also disclosed as a viscosity-reducing dipeptide. Among the disclosed methods, methods of reducing the viscosities of such formulations are also provided.

公开(公告)号：US20210236636A1

公开(公告)日：2021-08-05

申请号：US17262962

申请日：2019-07-30

Applicant: AMGEN INC.

Inventor： Michael John TREUHEIT ,  Pavan GHATTYVENKATAKRISHNA ,  Bharadwaj JAGANNATHAN

IPC: A61K39/395 ,  C07K16/46 ,  A61K47/26 ,  A61K47/14 ,  A61K47/18

Abstract: The present disclosure is directed to low pH pharmaceutical compositions and/or formulations comprising a masked antigen binding protein.

公开(公告)号：US20220259329A1

公开(公告)日：2022-08-18

申请号：US17616580

申请日：2020-06-05

Applicant: AMGEN INC.

Inventor： Pavan GHATTYVENKATAKRISHNA ,  Brendan AMER

IPC: C07K16/46 ,  A61P35/00 ,  C07K16/30

Abstract: New formats of bispecific binding constructs are described, as well as their methods of making. Additionally, uses in therapeutic indications are also described.

公开(公告)号：US20220227888A1

公开(公告)日：2022-07-21

申请号：US17616575

申请日：2020-06-05

Applicant: AMGEN INC.

Inventor： Johannes BROZY ,  Pavan GHATTYVENKATAKRISHNA ,  Brendan AMER

IPC: C07K16/46 ,  C07K14/725 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C07K14/765

Abstract: New formats of bispecific binding constructs with protease cleavable linkers are described, as well as their methods of making. Additionally, uses in therapeutic indications are also described.