Patent search ap:("AMGEN INC.") AND inv:"Reem TELMESANI" Page 1

1.

发明公开
PROCESS FOR RACEMIZING AND ISOLATING ATROPISOMERS OF 7-CHLORO-6-FLUORO-1-(2-ISOPROPYL-4-METHYLPYRIDIN-3-YL)PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE 审中-公开

公开(公告)号：US20230391771A1

公开(公告)日：2023-12-07

申请号：US18030685

申请日：2021-10-06

Applicant: AMGEN INC.

Inventor： Matthew G. BEAVER , Michael T. CORBETT , Yuanqing FANG , David D. FORD , Andrew T. PARSONS , Gabrielle ST-PIERRE , Reem TELMESANI

IPC: C07D471/04

CPC classification number: C07D471/04 , C07B2200/13 , C07B2200/07

Abstract: Provided herein is a process comprising heating a composition comprising (P)-compound A or a salt thereof and a solvent to a temperature of 250° C. to 350° C. to form racemized compound A. Also provided is a process for isolating (P)-compound A from a composition comprising (P)-compound A and a tartrate, as described herein. Further provided herein, is a process for isolating a free acid of a tartrate or a hydrate thereof from a composition comprising a tartrate, (P)-compound A, and an organic solvent.

2.

发明申请
PROCESS FOR RACEMIZING AND ISOLATING ATROPISOMERS OF 7-CHLORO-6-FLUORO-1-(2-ISOPROPYL-4-METHYLPYRIDIN-3-YL)PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE 有权

公开(公告)号：US20250122197A1

公开(公告)日：2025-04-17

申请号：US18987607

申请日：2024-12-19

Applicant: AMGEN INC.

Inventor： Matthew G. BEAVER , Michael T. CORBETT , Yuanqing FANG , David D. FORD , Andrew T. PARSONS , Gabrielle ST-PIERRE , Reem TELMESANI

IPC: C07D471/04

Abstract: Provided herein is a process comprising heating a composition comprising (P)-compound A or a salt thereof and a solvent to a temperature of 250° C. to 350° C. to form racemized compound A. Also provided is a process for isolating (P)-compound A from a composition comprising (P)-compound A and a tartrate, as described herein. Further provided herein, is a process for isolating a free acid of a tartrate or a hydrate thereof from a composition comprising a tartrate, (P)-compound A, and an organic solvent.

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