公开(公告)号：US20240013869A1

公开(公告)日：2024-01-11

申请号：US18025311

申请日：2021-08-30

Applicant: AMGEN INC.

Inventor： Ron Christopher Kelly ,  Mary Chaves ,  Marc A. Caporini ,  Fabrice Schlegel

IPC: G16C60/00 ,  G16C20/70 ,  G16C20/80

CPC classification number: G16C60/00 ,  G16C20/70 ,  G16C20/80

Abstract: A method of computational modeling to predict stability of a lyophilized drug product includes receiving model parameters describing a virtual cake, a virtual vial, a virtual stopper, and a virtual ambient environment. The method also includes computing, by implementing a computational model and at each of a plurality of virtual time steps, a change in water amount or concentration in the virtual cake, virtual air within the virtual vial, and the virtual stopper, in part by applying the model parameters to the computational model. The method also includes generating information for display to a user via a user interface.