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公开(公告)号：US20220305081A1
公开(公告)日：2022-09-29
申请号：US17618922
申请日：2020-06-23
Applicant: AMGEN INC.
Inventor： Ruozhen HU , Paolo MANZANILLO , Wenjun OUYANG
Abstract: Provided herein are methods of treating a subject with a tumor or cancer. In exemplary embodiments, the method comprises increasing an immune response against the tumor or cancer in the subject or increasing effector activity or reducing suppressive activity of T-cells in the subject. In exemplary embodiments, the method comprises administering to the subject a SIRPγ binder, e.g., SIRPγ inhibitor, in an amount effective to treat the tumor or cancer in the subject.
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