公开(公告)号：US20160024158A1

公开(公告)日：2016-01-28

申请号：US14776917

申请日：2014-03-14

Applicant: AMGEN INC.

Inventor： Ryan B. CASE ,  Benjamin M. ALBA ,  Alice BAKKER ,  Irwin CHEN ,  Amy N. DUGUAY ,  Monica FLORIO ,  Peng LI ,  Mark Leo MICHAELS ,  Mei-mei TSAI

IPC: C07K14/435 ,  A61K47/48 ,  C07K16/18

CPC classification number: C07K14/435 ,  A61K47/60 ,  C07K14/51 ,  C07K16/18 ,  C07K2319/31

Abstract: The present application is directed to avimers and peptides and various combinations thereof in addition to methods of making and using them.

Abstract translation: 除了制备和使用它们的方法之外，本申请涉及avimers和肽及其各种组合。

公开(公告)号：US20210163621A1

公开(公告)日：2021-06-03

申请号：US17046731

申请日：2019-04-10

Applicant: AMGEN INC. ,  Kite Pharma, Inc.

Inventor： Michael John Giffin ,  Melissa THOMAS ,  Christopher MURAWSKY ,  Ryan B. CASE ,  Lawren WU ,  Jed J. WILTZIUS ,  Ruben Alvarez RODRIGUEZ ,  Jun FENG

IPC: C07K16/30 ,  A61P35/00 ,  C12N15/86 ,  C07K14/705

Abstract: Antigen binding molecules, chimeric receptors, and engineered immune cells to DLL3 are disclosed in accordance with the invention. The invention further relates to vectors, compositions, and methods of treatment and/or detection using the DLL3 antigen binding molecules and engineered immune cells.