公开(公告)号：US09663476B2

公开(公告)日：2017-05-30

申请号：US14264731

申请日：2014-04-29

Applicant: AMGEN INC.

Inventor： Stephen A. Hitchcock ,  Albert Amegadzie ,  Wenyuan Qian ,  Xiaoyang Xia ,  Scott S. Harried

IPC: C07D295/108 ,  C07D241/04 ,  C07D295/15 ,  C07D241/08

CPC classification number: C07D241/04 ,  A61K31/495 ,  A61K31/551 ,  A61K33/00 ,  C07D213/36 ,  C07D241/08 ,  C07D243/08 ,  C07D295/15 ,  C07D333/20

Abstract: The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

公开(公告)号：US20150307457A1

公开(公告)日：2015-10-29

申请号：US14264731

申请日：2014-04-29

Applicant: AMGEN INC.

Inventor： Stephen A. Hitchcock ,  Albert Amegadzie ,  Wenyuan Qian ,  Xiaoyang Xia ,  Scott S. Harried

IPC: C07D241/04 ,  C07D241/08 ,  C07D295/15

CPC classification number: C07D241/04 ,  A61K31/495 ,  A61K31/551 ,  A61K33/00 ,  C07D213/36 ,  C07D241/08 ,  C07D243/08 ,  C07D295/15 ,  C07D333/20

Abstract: The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.