公开(公告)号：US11377474B2

公开(公告)日：2022-07-05

申请号：US16532344

申请日：2019-08-05

申请人： AMGEN INC.

发明人： Jeroen Bezemer ,  Ying Chen ,  Richard Crockett ,  Kevin Crossley ,  Sheng Cui ,  Liang Huang ,  Sian Jones ,  Asher Lower ,  Krishnakumar Ranganathan

IPC分类号： C07K7/06 ,  C07K1/107 ,  A61K38/00

摘要： A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.

公开(公告)号：US10407464B2

公开(公告)日：2019-09-10

申请号：US15300209

申请日：2015-04-03

申请人： AMGEN INC.

发明人： Jeroen Bezemer ,  Ying Chen ,  Richard Crockett ,  Kevin Crossley ,  Sheng Cui ,  Liang Huang ,  Sian Jones ,  Asher Lower ,  Krishnakumar Ranganathan

IPC分类号： C07K7/06 ,  C07K1/107 ,  A61K38/00

摘要： A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is a synthetic, eight amino-acid selective peptide agonist of the calcium sensing receptor. It is being developed as an intravenous treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney disease-mineral and bone disorder (CKD-MBD).