公开(公告)号：US20250011779A1

公开(公告)日：2025-01-09

申请号：US18697901

申请日：2022-10-04

Applicant: AMGEN INC.

Inventor： Jiamiao LU ,  Michael OLLMANN ,  Patrick COLLINS ,  Chi-Ming LI ,  Songli WANG

IPC: C12N15/113

Abstract: The present invention relates to compositions and methods for enhancing the gene silencing activity of oligonucleotide compounds. In particular, the invention relates to inhibiting the expression or activity of suppressor proteins, such as RAB18, ZW10, STX18, SCFD2, NAPG, SAMD4B, or VPS37A, to increase the efficacy of ligand-conjugated oligonucleotide compounds in reducing the expression of target genes in a cell.