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公开(公告)号：US20250066470A1
公开(公告)日：2025-02-27
申请号：US18435746
申请日：2024-02-07
Applicant: AMGEN INC.
Inventor： Sue J. SOHN , Marissa MOCK , Ian Nevin FOLTZ , Agnieszka KIELCZEWSKA , Kathy MANCHULENKO , Yannick BULLIARD , Xiaoshan MIN
Abstract: Provided herein are TIGIT binding proteins, CD112R binding proteins, and combinations thereof. Also provided are compositions comprising TIGIT binding proteins and CD112R binding proteins, optionally further comprising PD-1 binding proteins. Related conjugates, fusion proteins, nucleic acids, vectors, host cells and kits are additionally provided. Further provided are pharmaceutical compositions comprising a TIGIT binding protein, CD112R binding protein, or a combination thereof, optionally, further comprising a PD-1 antigen binding protein, or a conjugate, fusion protein, nucleic acid, vector, or host cell, and a pharmaceutically acceptable carrier, diluent, or excipient, and methods of treating subjects in need thereof.
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公开(公告)号：US20220017616A1
公开(公告)日：2022-01-20
申请号：US17375958
申请日：2021-07-14
Applicant: AMGEN INC.
Inventor： Sue J. SOHN , Marissa MOCK , Ian Nevin FOLTZ , Agnieszka KIELCZEWSKA , Kathy MANCHULENKO , Yannick BULLIARD , Xiaoshan MIN
Abstract: Provided herein are TIGIT binding proteins, CD112R binding proteins, and combinations thereof. Also provided are compositions comprising TIGIT binding proteins and CD112R binding proteins, optionally further comprising PD-1 binding proteins. Related conjugates, fusion proteins, nucleic acids, vectors, host cells and kits are additionally provided. Further provided are pharmaceutical compositions comprising a TIGIT binding protein, CD112R binding protein, or a combination thereof, optionally, further comprising a PD-1 antigen binding protein, or a conjugate, fusion protein, nucleic acid, vector, or host cell, and a pharmaceutically acceptable carrier, diluent, or excipient, and methods of treating subjects in need thereof.
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